21C Museum Hotel St. Louis

Hotels

About

21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

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TripAdvisor Rating:

132 Reviews | Write a Review
Absolute disappointment
Reviewed By Dizzy K March 2025

MEN AND WOMEN SHARE PUBLIC BATHROOMS Latest check-in times in the area. Desk staff unfriendly and have no interest in helping. DO NOT BOOK THROUGH CHASE. THE EDIT RIPOFF You will not receive...

Full Review
Idol Wold Dinner
Reviewed By Melissa A March 2025

Kevin at valet was extremely helpful. He shared lots of good information about things to check out and where to go. We visited Idol Wolf for dinner and Kevin made sure we knew where we were going and...

Full Review
Promising/exciting new hotel slowly diminishing due to Housekeeping and Management
Reviewed By Arron E March 2025

I’ve been visiting St. Louis for over 12 years now, and for a long time, I made a point of trying a new hotel each time — until I stayed at 21c. That first visit changed everything. Since then, it’s...

Full Review
Handicap AccessibleDowntownDowntown

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RecreationRecreation FacilitiesSpas

TripAdvisor Rating:

132 Reviews | Write a Review
Absolute disappointment
Reviewed By Dizzy K March 2025

MEN AND WOMEN SHARE PUBLIC BATHROOMS Latest check-in times in the area. Desk staff unfriendly and have no interest in helping. DO NOT BOOK THROUGH CHASE. THE EDIT RIPOFF You will not receive...

Full Review
Idol Wold Dinner
Reviewed By Melissa A March 2025

Kevin at valet was extremely helpful. He shared lots of good information about things to check out and where to go. We visited Idol Wolf for dinner and Kevin made sure we knew where we were going and...

Full Review
Promising/exciting new hotel slowly diminishing due to Housekeeping and Management
Reviewed By Arron E March 2025

I’ve been visiting St. Louis for over 12 years now, and for a long time, I made a point of trying a new hotel each time — until I stayed at 21c. That first visit changed everything. Since then, it’s...

Full Review