21C Museum Hotel St. Louis



21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

Get Directions

TripAdvisor Rating:

66 Reviews | Write a Review
Great hotel.
Reviewed By Esma Z April 2024

Staff was so nice. Great hotel. Kevin was always soo friendly and helpful. The hotel is beautiful. The museum inside is great. The view is amazing. It’s close to all the entertainment around. Only a...

Full Review
Sight seeing
Reviewed By kayleen e April 2024

The whole room was a 10/10 the beds and pillows were perfect the hotel is very clean and everyone was super friendly. The restaurant was amazing. The art is simply amazing.. we always felt safe in...

Full Review
Great service
Reviewed By Samantha G April 2024

Wonderful and fast service. Especially Josh! Someone from valet was always readily available and always kind. We required their services multiple times each day and were always provided prompt...

Full Review

What's Nearby

Good Press Cafe

Welcoming and serving as a communal meeting place for hotel guests and downtown residents alike, Good Press is…

Coffee Shops

Idol Wolf

Inspired by the rich culinary traditions of Spain, we take a playful approach to tapas style dining by…


Locust Street Athletic & Swim Club

Immersed within a historic St. Louis building that once thrived as a recreational haven, Locust Street Athletic and…

RecreationRecreation FacilitiesSpas