About
21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking
1528 Locust St
St. Louis,
MO
63103
TripAdvisor Rating:
230 Reviews | Write a ReviewWonderful hotel
Reviewed By mampaone September 2026We booked this hotel because a newspaper did a piece on St Louis when BA started flying here a couple of years ago, and the reporter stayed here. So, thank you, Mr Reporter, because it is a gem. The...
Full ReviewAmazing service
Reviewed By Jessica k September 2026Mae at the front desk was amazing! She was knowledgeable, kind and professional. Room was clean, the hotel was absolutely stunning.
Full ReviewAwesome Anniversary
Reviewed By Indigo R September 2026Anniversary trip was made special at this unique hotel and museum. Take the stairs from the lobby up to some remarkable art and exhibits. Rooms were clean and spacious great value and staff very...
Full ReviewWhat's Nearby
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TripAdvisor Rating:
230 Reviews | Write a ReviewWonderful hotel
Reviewed By mampaone September 2026We booked this hotel because a newspaper did a piece on St Louis when BA started flying here a couple of years ago, and the reporter stayed here. So, thank you, Mr Reporter, because it is a gem. The...
Full ReviewAmazing service
Reviewed By Jessica k September 2026Mae at the front desk was amazing! She was knowledgeable, kind and professional. Room was clean, the hotel was absolutely stunning.
Full ReviewAwesome Anniversary
Reviewed By Indigo R September 2026Anniversary trip was made special at this unique hotel and museum. Take the stairs from the lobby up to some remarkable art and exhibits. Rooms were clean and spacious great value and staff very...
Full Review