21C Museum Hotel St. Louis

Hotels

About

21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

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TripAdvisor Rating:

131 Reviews | Write a Review
Idol Wold Dinner
Reviewed By Melissa A March 2025

Kevin at valet was extremely helpful. He shared lots of good information about things to check out and where to go. We visited Idol Wolf for dinner and Kevin made sure we knew where we were going and...

Full Review
Promising/exciting new hotel slowly diminishing due to Housekeeping and Management
Reviewed By Arron E March 2025

I’ve been visiting St. Louis for over 12 years now, and for a long time, I made a point of trying a new hotel each time — until I stayed at 21c. That first visit changed everything. Since then, it’s...

Full Review
Norhing but terrific
Reviewed By TR26 March 2025

We have now stayed at 3 of the 21c museum hotels, and we aim to get to all of them. This location has lived up to our high expectations. Our corner king room was spacious and elegant. May I please...

Full Review
Handicap AccessibleDowntownDowntown

What's Nearby

Good Press Cafe

Welcoming and serving as a communal meeting place for hotel guests and downtown residents alike, Good Press is…

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Idol Wolf

Inspired by the rich culinary traditions of Spain, we take a playful approach to tapas style dining by…

Restaurants

Locust Street Athletic & Swim Club

Immersed within a historic St. Louis building that once thrived as a recreational haven, Locust Street Athletic and…

RecreationRecreation FacilitiesSpas

TripAdvisor Rating:

131 Reviews | Write a Review
Idol Wold Dinner
Reviewed By Melissa A March 2025

Kevin at valet was extremely helpful. He shared lots of good information about things to check out and where to go. We visited Idol Wolf for dinner and Kevin made sure we knew where we were going and...

Full Review
Promising/exciting new hotel slowly diminishing due to Housekeeping and Management
Reviewed By Arron E March 2025

I’ve been visiting St. Louis for over 12 years now, and for a long time, I made a point of trying a new hotel each time — until I stayed at 21c. That first visit changed everything. Since then, it’s...

Full Review
Norhing but terrific
Reviewed By TR26 March 2025

We have now stayed at 3 of the 21c museum hotels, and we aim to get to all of them. This location has lived up to our high expectations. Our corner king room was spacious and elegant. May I please...

Full Review