21C Museum Hotel St. Louis

Hotels

About

21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

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TripAdvisor Rating:

139 Reviews | Write a Review
Great, unique option in downtown St Louis
Reviewed By exposurebydjk May 2025

I stayed for a couple of nights while in town for business. I didn't know much about it going in, but really enjoyed it... The restaurant was good (drinks and food). Staff were attentive and polite...

Full Review
Mixed experience, mostly negative
Reviewed By Andrew G May 2025

I stayed at this hotel for 5 nights while I was in St Louis for a conference. My experience was extremely mixed but verging much more on the bad side. The good: - The rooms are big and spacious. The...

Full Review
Kevin Is a Gem at 21c Museum Hotel
Reviewed By Reggie J May 2025

I had an amazing experience with Kevin, the valet at the 21c Museum Hotel in downtown St. Louis. From the moment I pulled up, Kevin was friendly, professional, and incredibly personable. He greeted...

Full Review
Handicap AccessibleDowntownDowntown

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TripAdvisor Rating:

139 Reviews | Write a Review
Great, unique option in downtown St Louis
Reviewed By exposurebydjk May 2025

I stayed for a couple of nights while in town for business. I didn't know much about it going in, but really enjoyed it... The restaurant was good (drinks and food). Staff were attentive and polite...

Full Review
Mixed experience, mostly negative
Reviewed By Andrew G May 2025

I stayed at this hotel for 5 nights while I was in St Louis for a conference. My experience was extremely mixed but verging much more on the bad side. The good: - The rooms are big and spacious. The...

Full Review
Kevin Is a Gem at 21c Museum Hotel
Reviewed By Reggie J May 2025

I had an amazing experience with Kevin, the valet at the 21c Museum Hotel in downtown St. Louis. From the moment I pulled up, Kevin was friendly, professional, and incredibly personable. He greeted...

Full Review