About
21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking
1528 Locust St
St. Louis,
MO
63103
TripAdvisor Rating:
209 Reviews | Write a ReviewFun date night
Reviewed By Gabe P August 2026Mic was an awesome server! Super friendly and helpful. Showed us through the menu and made some great suggestions!
Full ReviewPerfect anniversary dinner spot!!
Reviewed By Hannah F August 2026Such a yummy and delightful experience. Every single dish was amazing, we couldn’t pick a favorite, and Mic took great care of us with recommendations and friendly service. Highly highly recommend
Full ReviewThank you, Mae!
Reviewed By Happiness30592836834 July 2026Wonderful place! Staff is especially caring and attentive. Great customer service, ambience and food. Maelisha and Drummond are amazing and highly recommend!
Full ReviewWhat's Nearby
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TripAdvisor Rating:
209 Reviews | Write a ReviewFun date night
Reviewed By Gabe P August 2026Mic was an awesome server! Super friendly and helpful. Showed us through the menu and made some great suggestions!
Full ReviewPerfect anniversary dinner spot!!
Reviewed By Hannah F August 2026Such a yummy and delightful experience. Every single dish was amazing, we couldn’t pick a favorite, and Mic took great care of us with recommendations and friendly service. Highly highly recommend
Full ReviewThank you, Mae!
Reviewed By Happiness30592836834 July 2026Wonderful place! Staff is especially caring and attentive. Great customer service, ambience and food. Maelisha and Drummond are amazing and highly recommend!
Full Review