About
21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking
1528 Locust St
St. Louis,
MO
63103
TripAdvisor Rating:
202 Reviews | Write a Review21c/MargFest/STL Cards
Reviewed By Morgan H July 2026I absolutely loved the room & staff during my recent stay. The room was elegant and beautiful. The late night staff was wonderful!! Extremely kind, funny and so helpful!! Thank you, to all the staff...
Full ReviewAppreciation of Service
Reviewed By Eric A July 2026The Front Desk is the star of the show. Had no issues fulfilling all of our requests and did so with no issues. I’d like to thank Mae as she has been exceptional during our 2 night stay
Full ReviewArtsy boutique hotel worth a look!
Reviewed By Joan S July 2026Did not stay overnight at this beautiful boutique hotel, we had lunch at the Idol Wolf and viewed the art gallery on the second floor. This historic building was originally a YMCA which 21c has...
Full ReviewWhat's Nearby
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TripAdvisor Rating:
202 Reviews | Write a Review21c/MargFest/STL Cards
Reviewed By Morgan H July 2026I absolutely loved the room & staff during my recent stay. The room was elegant and beautiful. The late night staff was wonderful!! Extremely kind, funny and so helpful!! Thank you, to all the staff...
Full ReviewAppreciation of Service
Reviewed By Eric A July 2026The Front Desk is the star of the show. Had no issues fulfilling all of our requests and did so with no issues. I’d like to thank Mae as she has been exceptional during our 2 night stay
Full ReviewArtsy boutique hotel worth a look!
Reviewed By Joan S July 2026Did not stay overnight at this beautiful boutique hotel, we had lunch at the Idol Wolf and viewed the art gallery on the second floor. This historic building was originally a YMCA which 21c has...
Full Review