21C Museum Hotel St. Louis



21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

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50 Reviews | Write a Review
Excellent Service Especially Tom
Reviewed By hennaf2021 February 2024

Look for TOM who would do extra effort to make it effortless for 21c museum clients. He and other hotel staff made our stay smooth, fun and welcoming. Looking forward to visiting 21c Museum. It’s not...

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When you want your hotel to be a sensory experience
Reviewed By Craig L February 2024

We are huge fans of all the 21c hotels. If you are looking for a unique place to stay with art galleries, fabulous food and drink, then a 21c is for you. We have stayed at all of them and the...

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Unique setting, fitness/swim center and cocktail bar
Reviewed By Brian H February 2024

The bar/restaurant is classy cool, the fitness center and aquatic zone are relaxing, and the massage services are top notch. Ask for Rae. Tom the valet is professional and helpful. The heart of the...

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