21C Museum Hotel St. Louis

Hotels

About

21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

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TripAdvisor Rating:

128 Reviews | Write a Review
Norhing but terrific
Reviewed By TR26 March 2025

We have now stayed at 3 of the 21c museum hotels, and we aim to get to all of them. This location has lived up to our high expectations. Our corner king room was spacious and elegant. May I please...

Full Review
Thanks Kevin!!
Reviewed By Myrina O March 2025

Kevin was amazing! Fast service and very polite! I would highly recommended using the valet service. They make sure your vehicle is taken care of downtown. Kevin gave me the upmost respect and I...

Full Review
Great hotel BUT- don't leave anything behind!
Reviewed By Jonathan M March 2025

We stayed at the 21C Hotel 3/6-3/9. The hotel and front desk staff were great. BUT, we mistakenly forgot to pack a new pair of expensive jeans and a portable speaker in ou room when we checked out...

Full Review
Handicap AccessibleDowntownDowntown

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TripAdvisor Rating:

128 Reviews | Write a Review
Norhing but terrific
Reviewed By TR26 March 2025

We have now stayed at 3 of the 21c museum hotels, and we aim to get to all of them. This location has lived up to our high expectations. Our corner king room was spacious and elegant. May I please...

Full Review
Thanks Kevin!!
Reviewed By Myrina O March 2025

Kevin was amazing! Fast service and very polite! I would highly recommended using the valet service. They make sure your vehicle is taken care of downtown. Kevin gave me the upmost respect and I...

Full Review
Great hotel BUT- don't leave anything behind!
Reviewed By Jonathan M March 2025

We stayed at the 21C Hotel 3/6-3/9. The hotel and front desk staff were great. BUT, we mistakenly forgot to pack a new pair of expensive jeans and a portable speaker in ou room when we checked out...

Full Review