21C Museum Hotel St. Louis

Hotels

About

21c Museum Hotels brings the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street. 21c Museum Hotel brings a new kind of cultural and travel experience to St. Louis, building upon the founders’ mission to integrate contemporary art into daily life. 21c St. Louis features exhibition, meeting and event space showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Take a peek inside. Other amenities include: Free Contemporary Art Museum, open 7 days a week, 365 days a year; 173 spacious guest rooms; Two 21c Suites; Chef-driven Food & Beverage options; On-property Fitness Center; Valet Parking

1528 Locust St
St. Louis, MO 63103

Get Directions

TripAdvisor Rating:

187 Reviews | Write a Review
my favorite hotel
Reviewed By Sarah H January 2026

One of the coolest hotels I've ever stayed at. The lobby is beautiful, with several sitting areas and two restaurants. When we were there the art gallery exhibit was called The Future is Female, with...

Full Review
Such a great experience!
Reviewed By 178staceyv January 2026

We loved everything about our stay! Food, super cool pool area, great cocktails, beautiful, inspiring art and the staff was super accommodating. Not to mention it’s close to so many things!

Full Review
Great potential... little things added up to a disappointing experience
Reviewed By jkmccue January 2026

This was my 5th stay at this hotel - my local staycation go-to. The hotel amenities make it feel like a nice little getaway: -Local Press is the onsite coffeeshop and has a lovely breakfast -Idol...

Full Review
DowntownDowntown

What's Nearby

Good Press Cafe

Welcoming and serving as a communal meeting place for hotel guests and downtown residents alike, Good Press is…

Coffee Shops

Idol Wolf

Inspired by the rich culinary traditions of Spain, we take a playful approach to tapas style dining by…

Restaurants

Locust Street Athletic & Swim Club

Immersed within a historic St. Louis building that once thrived as a recreational haven, Locust Street Athletic and…

RecreationRecreation FacilitiesSpas

TripAdvisor Rating:

187 Reviews | Write a Review
my favorite hotel
Reviewed By Sarah H January 2026

One of the coolest hotels I've ever stayed at. The lobby is beautiful, with several sitting areas and two restaurants. When we were there the art gallery exhibit was called The Future is Female, with...

Full Review
Such a great experience!
Reviewed By 178staceyv January 2026

We loved everything about our stay! Food, super cool pool area, great cocktails, beautiful, inspiring art and the staff was super accommodating. Not to mention it’s close to so many things!

Full Review
Great potential... little things added up to a disappointing experience
Reviewed By jkmccue January 2026

This was my 5th stay at this hotel - my local staycation go-to. The hotel amenities make it feel like a nice little getaway: -Local Press is the onsite coffeeshop and has a lovely breakfast -Idol...

Full Review
Secret Link