Holiday Inn Express & Suites St. Louis South I55

Hotels

About

South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55. Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association. Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, Saint Louis Zoo, Forest Park, River City Casino and much more! Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly. Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!

4250 Midamerica Ln
St. Louis, MO 63129

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TripAdvisor Rating:

76 Reviews | Write a Review
Perfect Holiday Inn Express
Reviewed By GGrig July 2026

Perfect Holiday Inn Express: The hotel is in a very good shape. Friendly front desk staff. Clean, comfortable room. Efficient A/C. Good breakfast. I wish all the hotels on my road trip were like this...

Full Review
Excellent hotel stay
Reviewed By Cammie A June 2026

Excellent hotel. Very clean. Easy check in. Nice and powerful shower. Plenty of room. Breakfast has a variety options that are hot but also grab and go items. Highly recommend cinnamon rolls...

Full Review
Smelly room, pool dirty, great breakfast though
Reviewed By Jessica B June 2026

Upon arrival, room 414 smelled awful, like a wet dog mixed with mold and dirty socks. I called downstairs and in the hotel's defense, the kind woman staff member offered us another room that did not...

Full Review
South/SouthwestSouth

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TripAdvisor Rating:

76 Reviews | Write a Review
Perfect Holiday Inn Express
Reviewed By GGrig July 2026

Perfect Holiday Inn Express: The hotel is in a very good shape. Friendly front desk staff. Clean, comfortable room. Efficient A/C. Good breakfast. I wish all the hotels on my road trip were like this...

Full Review
Excellent hotel stay
Reviewed By Cammie A June 2026

Excellent hotel. Very clean. Easy check in. Nice and powerful shower. Plenty of room. Breakfast has a variety options that are hot but also grab and go items. Highly recommend cinnamon rolls...

Full Review
Smelly room, pool dirty, great breakfast though
Reviewed By Jessica B June 2026

Upon arrival, room 414 smelled awful, like a wet dog mixed with mold and dirty socks. I called downstairs and in the hotel's defense, the kind woman staff member offered us another room that did not...

Full Review
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