Holiday Inn Express & Suites St. Louis South I-55



South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55. Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association. Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, Saint Louis Zoo, Forest Park, River City Casino and much more! Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly. Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!

4250 Midamerica Ln
St. Louis, MO 63129

Get Directions

TripAdvisor Rating:

65 Reviews | Write a Review
Clean, Crisp, and Quiet
Reviewed By beachykeen17 August 2023

Lovely quiet hotel right off 55. Jessica at the front desk got me into a suite on walk-up on a Saturday night. Excellent service. Annette in the kitchen provided a great breakfast spread of hot and...

Full Review
Low Cost Comfort
Reviewed By Angela W June 2023

Pleasantly suprised with how clean and quiet this hotel was. I stayed for one night on a road trip and Jessica, at the front desk, was very kind and helpful, as I had made no prior reservation...

Full Review
Nice place
Reviewed By CoopsFarmBoy June 2023

We found the hotel to be clean and well maintained. The hot and cold breakfast had a nice selection. The fitness room was nice and clean. The breakfast area was messy from the little children who...

Full Review
Handicap AccessibleSouth/SouthwestSouth

What's Nearby

Hampton Inn & Suites St. Louis South I-55

Conveniently located 12 miles from downtown St. Louis; offering free breakfast, Wi-Fi, parking; indoor pool, business center, fitness…


Fairfield Inn & Suites St. Louis South

WELCOME TO FAIRFIELD INN & SUITES ST. LOUIS SOUTH Fuel up for the day and start your day…


Suson Park Animal Farm

Country living is just around the corner for urban dwellers who can see farm animals at this charming,…

Family FunParks