Holiday Inn Express & Suites St. Louis South I55

Hotels

About

South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55. Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association. Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, Saint Louis Zoo, Forest Park, River City Casino and much more! Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly. Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!

4250 Midamerica Ln
St. Louis, MO 63129

Get Directions

TripAdvisor Rating:

72 Reviews | Write a Review
A Clean, Comfortable Hotel with Good Service
Reviewed By TravelerCentralFLA December 2025

My family and I stayed at the Holiday Inn Express in St. Louis. The hotel staff were very friendly and helpful. The check-in process went smoothly and didn’t take too long. The room was clean and...

Full Review
Nice
Reviewed By Shelz7 November 2025

Clean hotel. The front desk staff was very friendly and they were helpful. I would stay there again. The room was clean and quiet. It was very close to the highway, which is exactly what we...

Full Review
Decent mid priced hotel near the interstate
Reviewed By Deb62862 August 2025

Our party of two adults stayed at this hotel for three nights in August. We have previously stayed at the Hampton Inn next door to it, but found the beds to be very uncomfortable last time. So, we...

Full Review
South/SouthwestSouth

What's Nearby

Hampton Inn & Suites St. Louis South I55

Conveniently located 12 miles from downtown St. Louis; offering free breakfast, Wi-Fi, parking; indoor pool, business center, fitness…

AccommodationsHotels

Fairfield Inn & Suites St. Louis South

WELCOME TO FAIRFIELD INN & SUITES ST. LOUIS SOUTH Fuel up for the day and start your day…

Hotels

Best Western St. Louis Inn

100% Non-smoking hotel, located 15 minutes from downtown St. Louis. Comfortable accommodations with many amenities: indoor pool, complimentary…

Hotels

TripAdvisor Rating:

72 Reviews | Write a Review
A Clean, Comfortable Hotel with Good Service
Reviewed By TravelerCentralFLA December 2025

My family and I stayed at the Holiday Inn Express in St. Louis. The hotel staff were very friendly and helpful. The check-in process went smoothly and didn’t take too long. The room was clean and...

Full Review
Nice
Reviewed By Shelz7 November 2025

Clean hotel. The front desk staff was very friendly and they were helpful. I would stay there again. The room was clean and quiet. It was very close to the highway, which is exactly what we...

Full Review
Decent mid priced hotel near the interstate
Reviewed By Deb62862 August 2025

Our party of two adults stayed at this hotel for three nights in August. We have previously stayed at the Hampton Inn next door to it, but found the beds to be very uncomfortable last time. So, we...

Full Review
Secret Link