Holiday Inn St. Louis Southwest Route 66

AccommodationsHotels

About

Get Your Kicks on Route 66! With a convenient location along Historic Route 66 in Sunset Hills, the Holiday Inn St. Louis SW – Route 66 offers the best accommodations in town. At the junction of I-44 and I-270, the hotel is located less than two miles from Historic Kirkwood, and just 14 miles from the Gateway Arch and all the exciting attractions downtown St. Louis has to offer. Stay and play in St. Louis and experience a Cardinals game at Busch Stadium, a Blues game at Enterprise Arena, or come show your support for one of your most favorite traveling teams at the World Wide Technology Soccer Park. A visit to St. Louis wouldn’t be complete without a stop by the ever-so-popular St. Louis Science Center, St. Louis Aquarium, Missouri Botanical Gardens, Magic House, Six Flags, or the nationally accredited St. Louis Zoo. The hotel is also just a short drive to Webster University, Harris-Stowe State University, St. Louis University, Barnes Jewish Hospital, St. Louis Children’s Hospital, Mercy Hospitals, SSM, and Washington University’s top medical centers. Corporate and leisure travelers will be impressed with our newly renovated 213-room hotel and 15,500 square feet of flexible meeting space. Sunset Event Space, operated by Twisted Catering, will be the place to host meetings, weddings, and special events for years to come. Guests can also enjoy “Wakey Wakey a Breakfast Place” for a fresh start to the day, and lunch or dinner at the Award-Winning Twisted Tree Steakhouse adjacent to the hotel.

10709 Watson Rd.
St. Louis, MO 63127

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TripAdvisor Rating:

388 Reviews | Write a Review
Fantastic
Reviewed By Patricia M September 2025

We had stayed in 2 Crowne Plaza on this trip which were awful so wasn’t looking forward to this hotel. Well, we had a lovely surprise, great hotel. Looked new or at least completely newly renovated...

Full Review
I won't be staying here again
Reviewed By Cindy H September 2025

Tried to use the lobby for some quiet time at 6 am but the music was too loud to concentrate plus 2 TV's on. The air conditioner compressor was very loud in our room for an hour so it was hard to go...

Full Review
All my expectations were exceeded. PS: I stayed at this same facility in 2016. It has been noticeably updated many ways!
Reviewed By David B September 2025

I have stayed at many hotels in my life time both as a family and on business. I was very impressed with the cleanliness of this hotel. Everything was prestine. If I did not know better I would think...

Full Review
Pet FriendlySouth/SouthwestSouthwest

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TripAdvisor Rating:

388 Reviews | Write a Review
Fantastic
Reviewed By Patricia M September 2025

We had stayed in 2 Crowne Plaza on this trip which were awful so wasn’t looking forward to this hotel. Well, we had a lovely surprise, great hotel. Looked new or at least completely newly renovated...

Full Review
I won't be staying here again
Reviewed By Cindy H September 2025

Tried to use the lobby for some quiet time at 6 am but the music was too loud to concentrate plus 2 TV's on. The air conditioner compressor was very loud in our room for an hour so it was hard to go...

Full Review
All my expectations were exceeded. PS: I stayed at this same facility in 2016. It has been noticeably updated many ways!
Reviewed By David B September 2025

I have stayed at many hotels in my life time both as a family and on business. I was very impressed with the cleanliness of this hotel. Everything was prestine. If I did not know better I would think...

Full Review
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