Holiday Inn St. Louis Southwest - Route 66



Get Your Kicks on Route 66! With a convenient location along Historic Route 66 in Sunset Hills, the Holiday Inn St. Louis SW – Route 66 offers the best accommodations in town. At the junction of I-44 and I-270, the hotel is located less than two miles from Historic Kirkwood, and just 14 miles from the Gateway Arch and all the exciting attractions downtown St. Louis has to offer. Stay and play in St. Louis and experience a Cardinals game at Busch Stadium, a Blues game at Enterprise Arena, or come show your support for one of your most favorite traveling teams at the World Wide Technology Soccer Park. A visit to St. Louis wouldn’t be complete without a stop by the ever-so-popular St. Louis Science Center, St. Louis Aquarium, Missouri Botanical Gardens, Magic House, Six Flags, or the nationally accredited St. Louis Zoo. The hotel is also just a short drive to Webster University, Harris-Stowe State University, St. Louis University, Barnes Jewish Hospital, St. Louis Children’s Hospital, Mercy Hospitals, SSM, and Washington University’s top medical centers. Corporate and leisure travelers will be impressed with our newly renovated 213-room hotel and 15,500 square feet of flexible meeting space. Sunset Event Space, operated by Twisted Catering, will be the place to host meetings, weddings, and special events for years to come. Guests can also enjoy “Wakey Wakey a Breakfast Place” for a fresh start to the day, and lunch or dinner at the Award-Winning Twisted Tree Steakhouse adjacent to the hotel.

10709 Watson Rd.
St. Louis, MO 63127

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TripAdvisor Rating:

368 Reviews | Write a Review
Good location friendly staff
Reviewed By rusty_fwg January 2024

This is a regular holiday inn, not an express but does still have a lounging area where you can get a coffee and also has a pay section for other food items. Restaurant on site, has breakfast with...

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Dirty! Dirty!
Reviewed By plcjewel September 2023

Skip this hotel! Traveling from out of state and after car trouble, the repair shop offered a ride to this hotel. Staff was nice, but the room and bathroom were very small. Most importantly, it...

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Reviewed By minn_traveler612 May 2023

I saw that this place was under renovation, the entry was a bit of mess, but okay. What was weird was the way the bathroom door swept into the bathroom, making it very tight with the toilet and the...

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Handicap AccessiblePet FriendlySouth/SouthwestSouthwest

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