Holiday Inn St. Louis Southwest - Route 66

  • Accommodations Hotels
  • South/Southwest
  • Southwest

Get Your Kicks on Route 66! With a convenient location along Historic Route 66 in Sunset Hills, the Holiday Inn St. Louis SW – Route 66 offers the best accommodations in town. At the junction of I-44 and I-270, the hotel is located less than two miles from Historic Kirkwood, and just 14 miles from the Gateway Arch and all the exciting attractions downtown St. Louis has to offer. Stay and play in St. Louis and experience a Cardinals game at Busch Stadium, a Blues game at Enterprise Arena, or come show your support for one of your most favorite traveling teams at the World Wide Technology Soccer Park. A visit to St. Louis wouldn’t be complete without a stop by the ever-so-popular St. Louis Science Center, St. Louis Aquarium, Missouri Botanical Gardens, Magic House, Six Flags, or the nationally accredited St. Louis Zoo. The hotel is also just a short drive to Webster University, Harris-Stowe State University, St. Louis University, Barnes Jewish Hospital, St. Louis Children’s Hospital, Mercy Hospitals, SSM, and Washington University’s top medical centers. Corporate and leisure travelers will be impressed with our newly renovated 213-room hotel and 15,500 square feet of flexible meeting space. Sunset Event Space, operated by Twisted Catering, will be the place to host meetings, weddings, and special events for years to come. Guests can also enjoy “Wakey Wakey a Breakfast Place” for a fresh start to the day, and lunch or dinner at the Award-Winning Twisted Tree Steakhouse adjacent to the hotel.


Pet Friendly

$25.00 pet fee, per pet/per night. Must be 40 lbs. or less.

TripAdvisor Rating

364 Reviews | Write a Review
Great Staff, Some Issues
Reviewed By tcyrol January 2023

First, the staff at this Holiday Inn has been friendly and accommodating. They really have been great. That said, the property is going thru renovations (which was noted on the app when booking, so...

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Friendly Staff
Reviewed By Maeve C July 2022

Stayed here for 4 nights recently. I didn't know hotel was under renovation when booking or I wouldnt have booked. No Pool, No Lobby Bar and very run down common areas. Its a hotel undergoing...

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Noise unresolved
Reviewed By jilldryan1022 June 2022

Stayed at this hotel for an event. They are renovating their pool. There was a water leak right outside our window of our room on the 1st floor number. Apparently that's where the water's main is...

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