Holiday Inn St. Louis Southwest Route 66

Hotels

About

Get Your Kicks on Route 66! With a convenient location along Historic Route 66 in Sunset Hills, the Holiday Inn St. Louis SW – Route 66 offers the best accommodations in town. At the junction of I-44 and I-270, the hotel is located less than two miles from Historic Kirkwood, and just 14 miles from the Gateway Arch and all the exciting attractions downtown St. Louis has to offer. Stay and play in St. Louis and experience a Cardinals game at Busch Stadium, a Blues game at Enterprise Arena, or come show your support for one of your most favorite traveling teams at the World Wide Technology Soccer Park. A visit to St. Louis wouldn’t be complete without a stop by the ever-so-popular St. Louis Science Center, St. Louis Aquarium, Missouri Botanical Gardens, Magic House, Six Flags, or the nationally accredited St. Louis Zoo. The hotel is also just a short drive to Webster University, Harris-Stowe State University, St. Louis University, Barnes Jewish Hospital, St. Louis Children’s Hospital, Mercy Hospitals, SSM, and Washington University’s top medical centers. Corporate and leisure travelers will be impressed with our newly renovated 213-room hotel and 15,500 square feet of flexible meeting space. Sunset Event Space, operated by Twisted Catering, will be the place to host meetings, weddings, and special events for years to come. Guests can also enjoy “Wakey Wakey a Breakfast Place” for a fresh start to the day, and lunch or dinner at the Award-Winning Twisted Tree Steakhouse adjacent to the hotel.

10709 Watson Rd.
St. Louis, MO 63127

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TripAdvisor Rating:

379 Reviews | Write a Review
A real gem of a hotel on the west side of St. Louis
Reviewed By GlobalAssKicker March 2025

I stayed here earlier in the month and found their rates to be much more competitve than other chains, yet their rooms and hospitality far exceeded what I've experienced in other area places to stay...

Full Review
My girlfriend was in town, so we stayed here
Reviewed By Larry D February 2025

It's not far from my house and the great reviews posted were the reason that made me pick here! It is safe, clean, well run and well managed! The staff are friendly and there is lots of free...

Full Review
Great experience.
Reviewed By Don L February 2025

The front desk staff were very, very nice, polite and accommodating to all of our needs. Could not wish for a better interaction. Every time I stay at this Rt 66 Holiday Inn all team members are so...

Full Review
Handicap AccessiblePet FriendlySouth/SouthwestSouthwest

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TripAdvisor Rating:

379 Reviews | Write a Review
A real gem of a hotel on the west side of St. Louis
Reviewed By GlobalAssKicker March 2025

I stayed here earlier in the month and found their rates to be much more competitve than other chains, yet their rooms and hospitality far exceeded what I've experienced in other area places to stay...

Full Review
My girlfriend was in town, so we stayed here
Reviewed By Larry D February 2025

It's not far from my house and the great reviews posted were the reason that made me pick here! It is safe, clean, well run and well managed! The staff are friendly and there is lots of free...

Full Review
Great experience.
Reviewed By Don L February 2025

The front desk staff were very, very nice, polite and accommodating to all of our needs. Could not wish for a better interaction. Every time I stay at this Rt 66 Holiday Inn all team members are so...

Full Review